Beyond the SNARE: Munc18-1 chaperones α-synuclein
نویسندگان
چکیده
Early infantile epileptic encephalopathy (EIEE)-associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation.
منابع مشابه
Beyond the SNARE: Munc18-1 chaperones α-synuclein
641 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 214 No. 6 641–643 www.jcb.org/cgi/doi/10.1083/jcb.201608060 Early infantile epileptic encephalopathy (EIEE), also known as Ohtahara syndrome, is a debilitating neurological disorder that results in early-onset tonic seizures and severe intellectual disability. Heterozygous mutations in MUNC18-1 (also known as syntaxin binding protei...
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عنوان ژورنال:
دوره 214 شماره
صفحات -
تاریخ انتشار 2016